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Aptinyx | discovering and developing innovative therapies for challenging disorders of the brain and nervous system

Challenging disorders of the brain. Our proprietary compounds modulate. Involved in nerve cell. We seek to leverage our experience. Track record of success to rapidly advance. Development for patients in need. November 14, 2016. Aptinyx to Present Data for NYX-2925 in Models of Neuropathic Pain and Traumatic Brain Injury at Neuroscience 2016. November 10, 2016. September 13, 2016. July 13, 2016. Aptinyx Initiates Dosing in Phase 1 Clinical Study of Lead NMDA-Receptor Modulator, NYX-2925.

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Aptinyx | discovering and developing innovative therapies for challenging disorders of the brain and nervous system | aptinyx.com Reviews
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Challenging disorders of the brain. Our proprietary compounds modulate. Involved in nerve cell. We seek to leverage our experience. Track record of success to rapidly advance. Development for patients in need. November 14, 2016. Aptinyx to Present Data for NYX-2925 in Models of Neuropathic Pain and Traumatic Brain Injury at Neuroscience 2016. November 10, 2016. September 13, 2016. July 13, 2016. Aptinyx Initiates Dosing in Phase 1 Clinical Study of Lead NMDA-Receptor Modulator, NYX-2925.
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1 about us
2 about aptinyx
3 management team
4 board of directors
5 careers
6 science
7 news
8 aptinyx
9 discovers and develops
10 innovative therapies
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about us,about aptinyx,management team,board of directors,careers,science,news,aptinyx,discovers and develops,innovative therapies,nervous system,the nmda receptor,a critical regulator,communication,promising therapies,into clinical,latest news
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Aptinyx | discovering and developing innovative therapies for challenging disorders of the brain and nervous system | aptinyx.com Reviews

https://aptinyx.com

Challenging disorders of the brain. Our proprietary compounds modulate. Involved in nerve cell. We seek to leverage our experience. Track record of success to rapidly advance. Development for patients in need. November 14, 2016. Aptinyx to Present Data for NYX-2925 in Models of Neuropathic Pain and Traumatic Brain Injury at Neuroscience 2016. November 10, 2016. September 13, 2016. July 13, 2016. Aptinyx Initiates Dosing in Phase 1 Clinical Study of Lead NMDA-Receptor Modulator, NYX-2925.

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aptinyx.com aptinyx.com
1

Aptinyx | Management Team

http://www.aptinyx.com/about/management-team

Norbert G. Riedel, Ph.D. - President and Chief Executive Officer. Ashish Khanna - Chief Business Officer. Torsten M. Madsen, M.D., Ph.D. - Chief Medical Officer. Joseph R. Moskal, Ph.D. - Chief Scientific Officer. Patricia Adams - Vice President, Human Resources and Administration. Cassia Cearley, Ph.D. - Vice President, Research. David R. Houck, Ph.D. - Vice President, Drug Development Operations. M Amin Khan, Ph.D. - Vice President, Chemistry R&D. 1801 Maple Avenue, Suite 4300. Evanston, IL 60201.

2

Aptinyx | Board of Directors

http://www.aptinyx.com/about/board-of-directors

Wilbur H. Gantz III. Chairman of the Board. President, PathoCapital, LLC. Founder and Managing Director, Longitude Capital. Terry P. Gould. Partner and Head of Venture / Growth Equity Investments, Adams Street Partners. Liam Ratcliffe, M.D., Ph.D. Managing Director, New Leaf Venture Partners. Norbert G. Riedel, Ph.D. President and CEO, Aptinyx. James Topper, M.D., Ph.D. Managing General Partner, Frazier Healthcare Partners. 1801 Maple Avenue, Suite 4300. Evanston, IL 60201.

3

Aptinyx | About Aptinyx

http://www.aptinyx.com/about/about-aptinyx

Aptinyx Inc. was spun out of a predecessor company, Naurex Inc., following the acquisition of Naurex by Allergan in 2015. Allergan’s acquisition was focused on Naurex’s lead NMDA receptor modulators in clinical development as differentiated therapies for depression: Phase 3-ready rapastinel (formerly called GLYX-13) and Phase 2 drug candidate NRX-1074. Naurex had demonstrated. 1801 Maple Avenue, Suite 4300. Evanston, IL 60201. 2017 Aptinyx Inc. Terms of Use.

4

Aptinyx | Science

http://www.aptinyx.com/science

Our compounds work through modulation of the NMDA receptor a key regulator of communication among cells of the the brain and nervous system. Nerve Cell Communication: The Role of Synaptic Plasticity and the NMDA Receptor. The NMDA receptor receives signals from certain neurotransmitters (glutamate and glycine) and is critically important in normal brain and nervous system function. The activation and opening of NMDA receptor channels triggers a cascade of events resulting in synaptic plasticity. ...

5

Aptinyx | About Aptinyx

http://www.aptinyx.com/about

Aptinyx Inc. was spun out of a predecessor company, Naurex Inc., following the acquisition of Naurex by Allergan in 2015. Allergan’s acquisition was focused on Naurex’s lead NMDA receptor modulators in clinical development as differentiated therapies for depression: Phase 3-ready rapastinel (formerly called GLYX-13) and Phase 2 drug candidate NRX-1074. Naurex had demonstrated. 1801 Maple Avenue, Suite 4300. Evanston, IL 60201. 2017 Aptinyx Inc. Terms of Use.

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Longitude Capital: Venture Growth Investing in Life Sciences

http://www.longitudecapital.com/portfolio.html

Longitude Capital specializes in making venture growth investments in biotechnology and medical technology companies that seek to improve clinical outcomes, enhance quality of life and/or reduce system costs. We invest in both privately held and publicly traded life science companies through a variety of investment approaches. Since 2006, Longitude Capital has raised over $1.2 billion across three funds and demonstrated an ability to source, manage and exit attractive investments across multi...Following...

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Longitude Capital: Venture Growth Investing in Life Sciences

http://www.longitudecapital.com/news.html

Longitude Capital specializes in making venture growth investments in biotechnology and medical technology companies that seek to improve clinical outcomes, enhance quality of life and/or reduce system costs. We invest in both privately held and publicly traded life science companies through a variety of investment approaches. Since 2006, Longitude Capital has raised over $1.2 billion across three funds and demonstrated an ability to source, manage and exit attractive investments across multi...Following...

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New Leaf Venture Partners - Portfolio

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With the success of our entrepreneurs our portfolio has. 20 billion-dollar companies, 34 acquired companies,. And 39 companies taken public, with more to come. Artificial intelligence platform that confirms medication adherence in clinical trials and high-risk patient populations. New York, NY. Platform for small-molecule drugs that induce targeted degradation of disease-causing intracellular proteins. New Haven, CT. NLV III / GROWTH. NLV III / GROWTH. NLV III / GROWTH. Berkeley Heights, NJ. New York, NY.

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Longitude Capital: Venture Growth Investing in Life Sciences

http://www.longitudecapital.com/working_us.html

Longitude Capital specializes in making venture growth investments in biotechnology and medical technology companies that seek to improve clinical outcomes, enhance quality of life and/or reduce system costs. We invest in both privately held and publicly traded life science companies through a variety of investment approaches. Since 2006, Longitude Capital has raised over $1.2 billion across three funds and demonstrated an ability to source, manage and exit attractive investments across multi...Following...

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Longitude Capital: Venture Growth Investing in Life Sciences

http://www.longitudecapital.com/our_team.html

Longitude Capital specializes in making venture growth investments in biotechnology and medical technology companies that seek to improve clinical outcomes, enhance quality of life and/or reduce system costs. We invest in both privately held and publicly traded life science companies through a variety of investment approaches. Since 2006, Longitude Capital has raised over $1.2 billion across three funds and demonstrated an ability to source, manage and exit attractive investments across multi...Following...

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Longitude Capital: Venture Growth Investing in Life Sciences

http://www.longitudecapital.com/our_approach.html

Longitude Capital specializes in making venture growth investments in biotechnology and medical technology companies that seek to improve clinical outcomes, enhance quality of life and/or reduce system costs. We invest in both privately held and publicly traded life science companies through a variety of investment approaches. Since 2006, Longitude Capital has raised over $1.2 billion across three funds and demonstrated an ability to source, manage and exit attractive investments across multi...Following...

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Longitude Capital: Venture Growth Investing in Life Sciences

http://www.longitudecapital.com/index.html

Longitude Capital specializes in making venture growth investments in biotechnology and medical technology companies that seek to improve clinical outcomes, enhance quality of life and/or reduce system costs. We invest in both privately held and publicly traded life science companies through a variety of investment approaches. Since 2006, Longitude Capital has raised over $1.2 billion across three funds and demonstrated an ability to source, manage and exit attractive investments across multi...Following...

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Aptinyx | discovering and developing innovative therapies for challenging disorders of the brain and nervous system

Challenging disorders of the brain. Our proprietary compounds modulate. Involved in nerve cell. We seek to leverage our experience. Track record of success to rapidly advance. Development for patients in need. November 14, 2016. Aptinyx to Present Data for NYX-2925 in Models of Neuropathic Pain and Traumatic Brain Injury at Neuroscience 2016. November 10, 2016. September 13, 2016. July 13, 2016. Aptinyx Initiates Dosing in Phase 1 Clinical Study of Lead NMDA-Receptor Modulator, NYX-2925.

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