blog.rob.beagrie.com

Rob Beagrie's Blog

Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Or with the viable gene allele (c). Fyon, F. e...

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Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Or with the viable gene allele (c). Fyon, F. e...

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Rob Beagrie's Blog | blog.rob.beagrie.com Reviews

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Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Or with the viable gene allele (c). Fyon, F. e...

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blog.rob.beagrie.com

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Neurons - Rob Beagrie's Blog

http://blog.rob.beagrie.com/tag/neurons.html

Wed 01 October 2014. Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity dependent enhancers. I noticed a nice paper this week in Nature Neuroscience from Michael Greenberg's lab at Harvard Medical School. The paper discusses the identification of enhancers in neurons which are activated (or deactivated) when those neurons are stimulated by membrane de-polarization. The original paper can be found at: http:/ www.nature. Page 1 / 1.

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Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity–dependent enhancers - Rob Beagrie's Blog

http://blog.rob.beagrie.com/2014/10/01/enhancer-journal-club-genome-wide-characterization-of-neuronal-activity-dependent-enhancers

Enhancer Journal Club: Genome-wide identification and characterization of functional neuronal activity dependent enhancers. Wed 01 October 2014. The abstract is as follows:. Depolarization. In contrast, no putative enhancers with constant or decreased H3K27Ac after KCl treatment showed higher activity in the luciferase assay following the same treatment. Rob Beagrie - Proudly powered by pelican. Theme inspired by pelican-sober.

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GFI1 - Rob Beagrie's Blog

http://blog.rob.beagrie.com/tag/gfi1.html

Wed 07 October 2015. Enhancer Journal Club: Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. I read a neat little paper in Nature just before Christmas about enhancer hijacking, which I think is a particularly interesting topic. The original paper can be found at: http:/ www.nature.com/nature/journal/v511/n7510/full/nature13379.html. The abstract is as follows:. Medulloblastoma is a highly malignant. Page 1 / 1. Rob Beagrie - Proudly powered by pelican.

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Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression - Rob Beagrie's Blog

http://blog.rob.beagrie.com/2016/02/28/enhancer-journal-club-enhancer-runaway-and-gene-expression-evolution

Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. Sun 28 February 2016. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Fyon, F. et al., Enh...Akali...

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Enhancer Journal Club: Functional annotation of native enhancers with a Cas9-histone demethylase fusion - Rob Beagrie's Blog

http://blog.rob.beagrie.com/2015/11/05/enhancer-journal-club-functional-annotation-of-native-enhancers

Enhancer Journal Club: Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Thu 05 November 2015. I really enjoyed Eric Mendenhall's 2013 paper in Nature Biotechnology. Where he was able to target LSD1 histone demethylase activity to endogenous enhancers using TALE fusion proteins (read my thoughts on that paper here. So I was very interested to see a similar approach published earlier this year in Nature Methods. Luciferase activity either of the ODE or of enhancer 1 (Enh1)&...

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Seqonomics: How happy are 23andMe customers?

http://seqonomics.blogspot.com/2014/01/how-happy-are-customers-with-23andme.html

On making genomics useful. Sunday, 26 January 2014. How happy are 23andMe customers? In October last year, I joined several of my colleagues at the Sanger Institute. To order a bunch of direct-to-consumer genetic testing kits from 23andMe. The reason for the batch order was the associated discount. The total cost per person turned out to be around $130, of which $80 were for the kit and $50 for shipping from California to England. Which meant that we were able to get ours. There are dozens, if not hu...

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Enhancer Journal Club: Enhancer runaway and the evolution of diploid gene expression. I came across this very interesting theoretical paper about enhancer evolution a couple of months ago. And thought it was worth a little discussion. The paper comes from Frederic Fyon and others at the CNRS in Montpellier. The original paper can be found at PLOS Genetics, and it's well worth a read. Stronger enhancer homozygote (d). And enhancer locus heterozygotes (b). Or with the viable gene allele (c). Fyon, F. e...

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