We offer services focusing on the development of new remyelination therapies in Multiple Sclerosis. We use the cuprizone model, EAE and focal remyelination, and provide high-quality Research and Development (RD).
http://www.promyelo.de/
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ProMyelo - SFZ | promyelo.de Reviews
https://promyelo.de
We offer services focusing on the development of new remyelination therapies in Multiple Sclerosis. We use the cuprizone model, EAE and focal remyelination, and provide high-quality Research and Development (RD).
promyelo.de
Our Partners | ProMyelo - SFZ
http://www.promyelo.de/our-partners
Skip to primary content. Skip to secondary content. Research & Development. Steinbeis Forschungs- und Innovationszentren GmbH ProMyelo. Theaterplatz 1a D-52062 Aachen. 0049 241 80 35980.
In vitro Assays | ProMyelo - SFZ
http://www.promyelo.de/services/in-vitro-assays
Skip to primary content. Skip to secondary content. Research & Development. Cultured primary rat oligodendrocytes. 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase (CNPase). In Vitro High Content Screening Assays. High content screening (HCS) to evaluate Oligodendrocyte precursor cell (OPC) differentiation. For your experiments we provide:. Stringent protocols to generate relatively homogeneous ( 90% pure) and consistent populations of OPC. Cytotoxicity assays are used to check for false positive results.
Demyelination models | ProMyelo - SFZ
http://www.promyelo.de/multiple-sclerosis-models/demyelination-models
Skip to primary content. Skip to secondary content. Research & Development. Characteristic for Multiple Sclerosis lesions is the loss of myelinating oligodendrocytes and demyelination. ProMyelo’s modified cuprizone model shows consistent levels of axonal demyelination providing an excellent platform for qualitative and quantitative readouts of demyelination. Once mature oligodendrocytes are perturbed after a 3-week treatment, the progression to demyelination occurs without requiring further exposure....
Immunomodulation models | ProMyelo - SFZ
http://www.promyelo.de/multiple-sclerosis-models/immunomodulation-models
Skip to primary content. Skip to secondary content. Research & Development. Clinical paralysis scoring in vehicle vs. verum-treated animals. Experiments were performed using the MOG. CFA-Induced EAE in C57BL/6 Mice model. The development of new therapeutic strategies for treatment of multiple sclerosis (MS) including immunosuppressants, immunomodulators, and monoclonal antibodies require the use of appropriate animal models. In principal, EAE can be induced in two ways:. CFA-Induced EAE in C57BL/6 Mice.
Remyelination models | ProMyelo - SFZ
http://www.promyelo.de/multiple-sclerosis-models/remyelination-models
Skip to primary content. Skip to secondary content. Research & Development. Characteristics of the Cuprizone Model of Remyelination are presented. Myelination can be visualized by different techniques such as anti-PLP (proteolipid protein) immunohistochemistry or LFB/PAS (Luxol Fast Blue and Periodic Acid Schiff) stains. The most commonly used models used to study remyelination biology and pathology is the focal Lysophosphatidylcholine-induced Remyelination model and the Cuprizone Remyelination model.
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ProMyelo - SFZ
Skip to primary content. Skip to secondary content. Research & Development. Specialized standard and customized Tissue Analyses. State of the Art Screening Methods to identify, characterize. And evaluate Leads for Myelin-related Disorders. Models of Multiple Sclerosis. Evaluate Remyelination, Neuroprotection,. Oligodendrocyte pathology or Immunomodulation. ProMyelo GmbH is a highly specialized preclinical research organization offering services that focus on the development of new neural therapies, espec...
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