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ストレス老化シグナルによる解糖系酵素分子制御の誘導する癌化バリアー形成の解明
例えば古典的老化研究者Comfort (1960) によると、 老化とは死にやすくなること であり、それは時間に支配された生物現象と定義されていた。 しかし別の老化研究者Arking (1998, 老化のバイオロジー) の最新の言葉を借りると、老化の定義において、 １ 時間軸があまり重要で無いこと、２ 個体老化と細胞老化の共通性があること. 染色体末端に特殊なリピート配列(テロメア配列)が発見され 、テロメア配列長は細胞分裂回数により減少し、テロメア維持のために特殊なRNA依存性DNAポリメレース (テロメラーゼ) が存在し Blackburnら 、テロメラーゼ強制発現によりヒト初代線維芽細胞老化抑制する事が報告され、ある決着を見た。 Http:/ www.kyoto-u.ac.jp/ja/news data/h/h1/news6/2013 1/140224 2.htm. Http:/ www.nikkan.co.jp/news/nkx1020140226eaaj.html. 我々の仕事がようやくJCB IF;11点 オンラインに載りました。
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Anti-Aging
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